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26 HealthJournals

Ovary anatomy

The ovaries are female glands in which the eggs form and the female hormones estrogen and progesterone are made. These hormones play an important role in female traits, such as breast development, body shape, and body hair. They are also involved in the menstrual cycle, fertility, and pregnancy. There is one ovary on each side of the uterus.

Ovarian cancer types

Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer are diseases in which cancer cells form in the tissue covering the ovary or lining the fallopian tube or peritoneum. These cancers are staged and treated the same way. Learn about the risk factors, diagnosis, and treatment of these cancers.

Ovarian cancer risks

One-fifth of ovarian cancers are hereditary and occur in families. Inherited variants in particular genes, such as BRCA1 and BRCA2, account for 65 to 85% of hereditary ovarian cancers. Variants in the MLH1 or MSH2 gene, associated with Lynch syndrome, account for 10 to 15% of hereditary ovarian cancers. Learn more about these risk genes.

Ovarian cancer screening and prevention

Ovarian cancer is the second most common gynecologic cancer in the United States. It causes more deaths than any other cancer of the female reproductive system. There is no simple and reliable way to screen for ovarian cancer in women who do not have any signs or symptoms. Learn about rectovaginal pelvic exam, transvaginal ultrasound, and CA-125 blood test.

Ovarian cancer treatment

Ovarian cancer is often treated with surgery, and an oophorectomy removes one or both ovaries. The same operation, sometimes with removal of the fallopian tubes, can lower the risk of ovarian cancer in women at high risk, such as those with BRCA gene mutations.

Ovarian cancer research

Ovarian cancers begin in the epithelial cells that line the fallopian tubes or peritoneum as well as the ovaries — collectively called epithelial ovarian cancers. Other types of ovarian cancer arise in other cells, including germ cells, also called oocytes or egg cells, and stromal cells, which produce hormones.

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